|
KMID : 0383819720190030005
|
|
Tuberculosis and Respiratory Diseases
1972 Volume.19 No. 3 p.5 ~ p.12
|
|
|
Clinical Experience with Rifainpicin in the Retreatment of 46 Cases of Advanced Pulmonary Tuberculosis
|
|
홍빙표(洪氷杓)/Young-Pyo Hong
송호성(宋浩星)/Ho-Sung Song
|
|
|
Abstract
|
|
|
46 patients of sputum positive advanced pulmonary tuberculosis were retreated with
rifampicin being the major chemotherapeutic drug, 37 cases (80%) attained negative
conversion. The factors which knave influenced the result of the retreatment were
extent of diseases, history of diseases and chemotherapy, numbers of drug resistance
and combining antituberculosis drug (s). Four out of five cases of intermittent treatment
achieved negative conversion.
The time of negativation were one to eight months after the initiation of treatment on
concentration smears and between one to five months on cultures, So-called smear
positive and culture negative cases occurred in 28 cases(76%) out of 37 converted cases,
the duration being from one to six months,
Criteria of resistance to rifampicin was judged as growth in 0.4 mcg/ml by Youman's
liquid media. Because tubercle bacilli have grown invariably in that concentration in
treatment failure cases, and the strains of converted cases have never grown in that
concentration before negative Conversion.
There were no primary resistance to rifampicin in 232 pre-treatment strains of sputum
of tuberculosis patients judged by the above mentioned criteria. Over-all radiographic
changes were minimal. There were four cases (6.2%) of hepatic dysfunction with
jaundice out of 64 patients who had one or more months of treatment. Other untoward
reactions were negligible.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
  
|